College friends, Mel and Sharon, have spent the last ten years working together creating short cartoons and advertisements. When they decide to make a full length animated film based on Mel's troubled fearless life, they find success but this does not make their path easier. Sharon suffers from a stroke, Mel's drinking and life of excess worsens and her mom dies in prison. The duo's relationship strains but they reunite for a second film, this time focused on Sharon. The two confront their demons as they try to embrace their creativity, cope with life, and find redemption.